MOLECULAR MECHANISM OF THE CELL DEATH INDUCED BY THE HISTONE DEACETYLASE PAN INHIBITOR LBH589 (PANOBINOSTAT) IN WILMS TUMOR CELLS.

Molecular Mechanism of the Cell Death Induced by the Histone Deacetylase Pan Inhibitor LBH589 (Panobinostat) in Wilms Tumor Cells.

Wilms tumor (WT) is an embryonic kidney cancer, for which histone acetylation might be a therapeutic target.LBH589, a novel targeted agent, suppresses histone deacetylases in many Split Reins tumors.This study investigated the antitumor activity of LBH589 in SK-NEP-1 and G401 cells.SK-NEP-1 and G401 cell growth was assessed by CCK-8 and in nude mic

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Formation of Border Line between Kazakhstan and Siberia in 1920s - Early 1930s (The Case of Cherlaksky District)

The process of changing the border line of the Akmola province of the Kazak Autonomous Republic (until 1925 - the Kyrgyz Republic) of the Autonomous Republic with the adjacent territory of the Omsk District of the Siberian Territory (until 1925 - the Omsk Province), consisting in the transition of the Cherlak District (Stepanovskaya, Dobrovolskaya,

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